List of Famous people born in Mtskheta-Mtianeti, Georgia

Tochinoshin Tsuyoshi is a Georgian professional sumo wrestler from Mtskheta. He is a member of the Kasugano stable and made his professional debut in March 2006. He reached the top makuuchi division just two years later in May 2008. After a long hiatus due to injury, he began his comeback from the rank of makushita 55 in March 2014, logging four championships in a row in lower divisions on his way back to the top division in November 2014. He has eleven special prizes, six for Fighting Spirit, three for Technique, and two for Outstanding Performance, as well as two kinboshi or gold stars for defeating yokozuna. In January 2018 he took his first top-division yūshō (championship). In May 2018, after finishing as runner-up with a 13–2 record and a total of 37 wins in his last three tournaments, he was promoted to ōzeki. He was demoted to sekiwake after posting losing records in the first two tournaments of 2019, but returned to ōzeki after winning ten matches at the May 2019 basho.

Tamar the Great reigned as the Queen of Georgia from 1184 to 1213, presiding over the apex of the Georgian Golden Age. A member of the Bagrationi dynasty, her position as the first woman to rule Georgia in her own right was emphasized by the title mepe ("king"), afforded to Tamar in the medieval Georgian sources.

Anna Dogonadze is a German trampoline gymnast of Georgian origin who won a gold medal in the event of trampolining at the 2004 Summer Olympics.

Vakhtang I Gorgasali, of the Chosroid dynasty, was a king of Iberia, natively known as Kartli in the second half of the 5th and first quarter of the 6th century.

Nikolai Vasilievich Bugaev was a prominent Russian mathematician, the father of Andrei Bely.

Giorgi (George) V. Tsereteli FRAS was a Georgian scientist and public benefactor, founder of the well-known Georgian scientific school of Oriental Studies. He founded both the Faculty of Oriental Studies of the Tbilisi State University (TSU) the Institute of Oriental Studies of the Georgian National Academy of Sciences (GNAS), the latter of which he was the first Director. He was also an Academician of GNAS, a Meritorious Scientific Worker of Georgia, a Doctor of Philological Sciences and a Professor.

Pharnavaz I was a king of Kartli, an ancient Georgian kingdom known as Iberia in classical antiquity. The Georgian Chronicles credits him with being the first monarch founding the kingship of Kartli and the Pharnavazid dynasty, while other independent chronicles, such as The Conversion of Kartli make him the second Georgian monarch. Based on the medieval evidence, most scholars locate Pharnavaz's rule in the 3rd century BC: 302–237 BC according to Prince Vakhushti of Kartli, 299–234 BC according to Cyril Toumanoff and 284–219 BC according to Pavle Ingoroqva. Pharnavaz's rise, advent and imperial expansion of the Iberian monarchy was directly tied to the victory of Alexander the Great over the Achaemenid Empire. Pharnavaz ruled under the suzerainty of the Seleucid Empire.